Sentence examples for by decreasing its binding from inspiring English sources

It is possible that geminin overexpression prevents TopoIIα SUMOylation by decreasing its binding to the SUMOylating complex RanBP2/Ubc9.

Gong et al. (2006) suggested that BaP may suppress the transcription of the HSP70 gene by reducing the amount of heat shock factor-1 and by decreasing its binding to the heat shock element.

Tyr phosphorylation of β-catenin leads to its stabilisation and nuclear signalling activity by decreasing its binding affinity to E-cadherin and the APC/GSK β/Axin destruction complex (Coluccia et al, 2007).

However, Martinou and colleagues have shown that Bax activation is inhibited by cholesterol accumulation, essentially by decreasing its membrane binding property.

The activity of this compact dimeric form is reduced by decreasing its DNA-binding affinity and probably further by burying important amino acids of the TA.

A T at position -52 disrupts what is otherwise a highly favorable Sp1 binding site and decreases its binding by 8 10 fold [2].

We have previously shown that LPS-induced S-nitrosylation of heterogeneous nuclear ribonucleoprotein (hnRNP -A/B inhnRNP -A/B actinhibits a constitstive tractivityessor of the OPN trasscription by significantly deconstitutive DNA binding activity.

Infliximab (Remicade®; Centocor, Inc., Malvern, PA, USA), etanercept (Enbrel®; Immunex Corp ,Seattle, WA, USA), and adalimumab (Humira™; Abbott Laboratories, Abbott Park, IL, USA) are designed to modulate the inflammatory cascade of RA by binding TNF, thereby decreasing its bioavailability.

Therefore, these results suggest that N/OFQ causes an increase in ANP secretion in cultured neonatal cardiac myocytes by decreasing cAMP through its binding sites.

The TIRs and adjacent sequences of several DNA transposons have been shown to be functionally significant with mutations of these sequences reducing transposition frequency by decreasing the binding of transposase23,24.

Unfortunately, metronomic S-1 dosing resulted in impaired delivery of PEG-coated "cationic" liposomes into tumor tissue, presumably by decreasing the binding sites on tumor blood vessels available for the liposomes.