Sentence examples for by decreasing its affinity from inspiring English sources
Second, when PAI-1 is bound to the plasminogen activator, it is able to modulate cell adhesion by decreasing its affinity for vitronectin and increasing its affinity for endocytic receptors, thus enabling cell migration.
Hyperacetylation of Hsp90 by knocking down the deacetylase HDAC6 (histone deacetylase 6) negatively regulates the function of Hsp90 by decreasing its affinity for critical co-chaperones [ 22].
Recent findings shown also that VRT-325 exhibits undesirable effect and inhibits the ATPase activity of ΔF508-CFTR by decreasing its affinity for ATP (Kim et al, 2010).
Interestingly, phosphorylation at another residue (Ser112) modulates PPAR γ activity with positive effects on glucose and lipid metabolism in vivo possibly by decreasing its affinity for endogenous ligands.
In the modified conformational state, CaM is likely to alter its affinity to different targets by increasing and decreasing its affinity to certain proteins.
Mutations V174A, V174C, and A404V increased the Kcat value by 1.5 2 folds while decreasing its affinity to cellobiose.
Tyr phosphorylation of β-catenin leads to its stabilisation and nuclear signalling activity by decreasing its binding affinity to E-cadherin and the APC/GSK β/Axin destruction complex (Coluccia et al, 2007).
Biophysical analysis confirms that modification of XPA by adenine propenal decreases its affinity for damaged DNA.
These reports suggest that the phosphorylation of CLIP-170 by AMPK may decrease its affinity for tubulins or shift the binding site to more distal ends of the microtubules than the binding site of nonphosphorylated CLIP-170; however, more detailed reports are necessary to clarify the precise mechanisms (Lee et al. 2010).
The activity of this compact dimeric form is reduced by decreasing its DNA-binding affinity and probably further by burying important amino acids of the TA.
Phosphorylation of TauT by protein kinase C decreases its affinity for taurine, and activation of this kinase in placental villous fragments and trophoblast cells leads to reduced TauT activity.
