Even though reports on platelet reactivity in patient with chronic kidney disease show conflicting results [ 23], it has been attributed to an acquired thrombocytopathy characterized by decreased aggregation of platelets in response to stimuli.
The purpose of the dialysis is to decrease aggregation of nanoparticles during centrifugation.
Inhibitors of sirtuin-2 deacetylase (SIRT2) have been shown to be protective in various models of Huntington's disease (HD) by decreasing polyglutamine aggregation, a hallmark of HD pathology.
With increasing EON, the packing parameter decreases and spherical micelles may be formed by decreasing the aggregation number.
We also confirmed a significant occurrence of polyP tracts following a polyQ domain, which might hinder its aggregation by decreasing the probability of the polyQ region to form a β-rich state 17.
The α crystallin core domain peptides FI and LT had the strongest protective effects and decreased the aggregation of tubulin by ∼42 44%.
"THC is known to be a potent antioxidant with neuroprotective properties, but this is the first report that the compound directly affects Alzheimer's pathology by decreasing amyloid beta levels, inhibiting its aggregation," lead author Chuanhai Cao, of the University of South Florida's Byrd Alzheimer's Institute said in a release.
Parasitism could have a stabilizing effect on the population dynamics of the fruit flies, by decreasing population growth, and thus decreasing the probability of over-aggregation at low resource densities.
The αB crystallin peptides, 113FISREFHR120 and 156ERTIPITRE164, inhibited microtubule disassembly by ∼26 36%, and the peptides 113FISREFHR120 and 131LTITSSLSSDGV142 decreased the thermal aggregation of tubulin by ∼42 44%.
Wt αB crystallin increased microtubule assembly by ∼41%, had no effect on the microtubule disassembly, and decreased the thermal aggregation of tubulin by 65%.
