Citrulline is a major precursor of arginine by de novo synthesis in the kidneys.
Cr is derived from dietary sources in the gastrointestinal tract, or by de novo synthesis synthesis primarily in the liver.
During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids.
All the evidences demonstrate that adult neurons have a lower capacity to compensate for a cholesterol deficit by de novo synthesis in comparison to astrocytes.
The four newly-found pathways of vanillin biosynthesis were as follows: shikimic acid pathway of glucose by de novo synthesis; and oxidation of cresol, capsaicin, and vanilla alcohol.
For example, albumin in thyroid gland was found to originate from blood rather than by de novo synthesis [16].
Ceramide is generated by de novo synthesis or hydrolysis of plasma membrane sphingomyelin via the action of sphingomyelinases (SMases).
Individual σ factors can either be regulated by de novo synthesis on the transcriptional or translational level or on the activity of pre-existing factors.
Thus, the dual provision of PLP by de novo synthesis and salvage indicates necessity and importance of this cofactor for the survival of yeast and other organisms.
A suitable steady state level of available ubiquitin monomers is provided by de novo synthesis of ubiquitin and recycling of ubiquitin following cleavage from their target proteins.
Uridine is essentially cleared in a single pass through the liver and is replaced by "new uridine" formed by de novo synthesis [7].
