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This notion is supported by data demonstrating a stronger association between SID and bicarbonate than that between chloride and bicarbonate [ 31].

The latter is supported by data demonstrating a moderate reduction of plasmablast numbers by ~50% in the blood of belimumabtreated SLE patients [ 15].

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Linkage analysis data are strongly supported by experimental data demonstrating a role for these candidate genes in ozone and PM susceptibility (Cho et al. 2005; Kleeberger et al. 2000).

This idea seems to be supported by previous data demonstrating a decrease in PMN function 5 and potential modifications of both the innate and adaptive immune systems in cows with endometritis.

It would have been most interesting to see whether or not CEPO would have had a beneficial effect in the above settings as the risks of serious adverse events may be reduced as confirmed by preclinical data demonstrating a tissue protective effect with CEPO in models of myocardial infarction [ 28, 51, 52] and renal disease [ 29, 53, 54].

Tests of moderation by sex were also supported by our own data demonstrating a preponderance for women to report more life events as extremely stressful in all of the measured life domains (supplementary Tables A1 and A2, available in an online appendix at http://care.diabetesjournals.org/cgi/content/full/dc09-1027/DC1).

This view is also supported by recent imaging data demonstrating a correlation between tactile hyperacuity and cortical map size of the fingers in the primary somatosensory cortex (Duncan and Boynton, 2007).

However, a significant downregulation of TGFBI expression has been demonstrated in HT29 colon cancer cells [ 15] and in different types of primary human cancers [ 15, 29- 32], which is further substantiated by the present data demonstrating a correlation between promoter hypermethylation and TGFBI silencing in human lung and prostate cancer cells.

This theory is supported by the large amount of experimental data demonstrating a direct correlation between the resistance to oxidative stress and the lifespan in different organisms [16,21].

91 In the post-chemotherapy setting, both abiraterone and enzalutamide are supported by Phase III data demonstrating an OS benefit, but the optimal approach to sequencing them is unknown.

Specific involvement of NOX enzymes is suggested by clinical data demonstrating an upregulation of NOX2 in cardiomyocytes in patients who had died after MI [ 65].

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