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Although conformational disorder is increasingly recognized as an important property of proteins involved in cellular signaling and regulation, it is poorly modeled by current computational methods.
Alpha-helical protein regions and β-sheets were identified by current computational methods (www.swissmodel.expasy.org).org
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Unfortunately, the prediction accuracies of current computational methods are still inferior compared to experiments.
We also discuss the current computational methods for investigating turbine wake flows.
We recently developed a novel computational tool: Presaging Critical Residues in Protein interfaces (PCRPi), that proved to be highly accurate and competitive with current computational methods [7].
However, our current computational method is not without limitations.
The proportion of healthy tissue in a sample can vary widely even among samples pre-selected to have a high cancerous cell content using pathological estimates [ 20- 23], thereby introducing variability into expression profiles that cannot be removed by current computational pre-processing methods.
Then we present an example of how the current approach to visualize time series of meteorological images can be improved by computational methods, particularly by feature tracking.
By uploading analyses generated by the computational methods they develop, bioinformatics developers will potentially reach out to more users unfamiliar with their tools.
These results were corroborated by other computational methods (see the Supporting Information for details).
Current computational target prediction methods use only the miRNA sequence as input.
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