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With this said, we compute the pairwise distance of two genes by creating a gene set with only those two genes as members.
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AnGST can account for gene tree phylogenetic uncertainty by creating a "chimeric" gene tree via the amalgamation of bootstrap replicates.
Honey bee researchers suspected that the first Official Gene Set (OGSv1.0), generated by creating a consensus gene set with GLEAN [ 1, 17], was incomplete, as it comprised only 10,157 genes, far fewer than expected based on the estimate of ~13,600 genes in D. melanogaster at the time.
We showed in this study that met1 locates to a region of the Ambystoma linkage map that has been structured by chromosomal rearrangements, creating a gene order that has not been observed in any other vertebrates.
Sequential testing of these variants identified a single SNP that resulted in increased gene expression by creating a transcription factor binding site for SORT1, a gene shown to regulate hepatic VLDL secretion.
It partitions a graph into connected subgraphs by creating a cluster for every gene and then merging two clusters if a gene in one of the clusters is orthologous to a gene in the other one.
We constructed empirical null distributions of DN/DS and PN/PS ratios (in short " N/ S ratios") by creating a series of random gene sets and recomputing new statistics on these gene sets.
In contrast to the approach of disabling a gene by creating a large deletion, the production of a null mutant by such a small intervention would be unlikely to cause collateral damage.
We accomplished this by creating a network of these genes and determining how many 1st order connections each gene had with the other genes in the network.
We have attempted to address these questions by creating a map that connects genes via pathways to hallmarks.
We have shown that indeed the sap gene is also involved in phage resistance and most likely is the receptor of AP50c phage by creating a targeted deletion of this gene and showing that the Δ sap strain is phage resistant (manuscript in preparation).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com