In 1949 Ertl developed a technique for transtibial osteomyoplastic amputation which restored the intraosseous pressure through canal obliteration and expanded the area of terminal support by creating a bony bridge between the fibula and distal tibia [4].
In oncological settings, TR is usually implemented by creating a "functional" bridge between scientists working in the field of basic research and researchers involved in the early phases (phase I-II) of clinical research through ad hoc collaborative efforts.
It builds on the curation of the CDC HuGENet info literature database [ 3] in part by adding molecular and ontological annotation creating a bridge between epidemiological and molecular information.
We are working *with* that mentality by creating an institutional bridge into these high performing networks, and short circuiting the time it generally takes to amass a top tier network.
Other approaches involve improving the axonal growth of homotopically transplanted neurons by creating a growth supporting bridge, via cografting various cell types along the nigrostriatal axis [ 25], or by stimulation of the localised release of GDNF or the excitatory amino acid kainic acid, [ 12, 26– 28].
And in a world-first, the public will be able to interact with the bridge's display by creating a custom design that will be projected onto the bridge just seconds after being logged via a touch screen located outside Luna Park.
"One gets this done by creating a for-profit e-intermediary to bridge consumers and government," said an e-mail sent to reporters by Jon Fisher, founder of NetClerk, a company that helps governments process licenses and forms.
By creating a satellite office, a sort of "bridge" between your city's startups and Silicon Valley, you can have the best of both worlds.
Intriguingly, RNAP IV Bridge Helices also contain an additional two amino acid deletion, which would cause an even more radical change in the Bridge Helix by creating a local 180° twist of the α-helical structure.
