Sentence examples for by counteracting the function from inspiring English sources
Possible modes of action of Vpx could be by counteracting the function of cellular antiviral genes, or induction of important cofactors lacking in monocytes and required e.g. for cell cycle progression [38], [39].
The spliced HAC1 transcript produces the Hac1p basic leucine zipper transcription factor that binds to the UPR element of genes such as KAR2 but also regulates UAS INO containing promoters by counteracting the function of Opi1p (Cox and Walter 1996).
However, in several instances KDM6 enzymes can also be regarded as tumor suppressor genes by counteracting the oncogenic function of PcG proteins, for example by controlling the INK4A/ARF locus that comprises tumor suppressor genes p16INK4A and p14ARF involved in cellular senescence.
A complementary scenario would imply that late-onset transcriptional repressor(s) begin counteracting the function of the notochord activator(s) by the time Stage 2 is reached.
A gatekeeper of VEGF function is angiopoietin-2 (Ang-2) and has been shown to breach the endothelial barrier function by counteracting the inhibitory effect of Ang-1 [ 7].
While it is currently unclear how these proteins prevent NHEJ, the observations that DSBs flanked by telomeric repeats show reduced DNA ligase IV binding [ 36 ] suggest that they might function by counteracting the loading of NHEJ proteins.
In the autoimmune T cell-mediated arthritis that develops as a result of IL-1 receptor antagonist deficiency, TLR2 protects mice from severe arthritis by controling Treg function and by counteracting the production of IFNγ and IL-17 [ 8].
Alternatively, TAL1-recruited PAD4 can function as a corepressor by counteracting the activating H3R17me2a mark by PRMT4, thereby inhibiting the expression of the CTCF-encoding gene.
Among its various functions, NO has been found to increase susceptibility to oxidative DNA damage by counteracting the genoprotective effect of the adenosine-activated cAMP pathway [ 18].
The compound appears to reduce the risk of psychotic disorders, by counteracting the effects of THC.
