Sentence examples for by coordinating conformational changes from inspiring English sources
P-gp couples drug efflux with ATP hydrolysis by coordinating conformational changes in the drug binding sites with the hydrolysis of ATP and release of ADP.
The properties of two distinct molecular hinges in the Bridge Helix of RNAP determine the functional contribution of this domain to key stages of the NAC by coordinating conformational changes in surrounding domains.
In combination with the previously identified C-terminal hinge region, the data reinforces the overarching concept that the Bridge Helix plays a predominantly nanomechanical role during the translocation stage of the NAC by coordinating conformational changes in surrounding domains.
By correlating fusion kinetics with specific, site-directed alterations in E, we have sought to determine the rate-limiting molecular events, the number of WNV E trimers needed to fuse, and the mechanism for coordinating conformational change among the several trimers that generate a single fusion pore.
It was suggested that long transverse helix HL of ND5, a proposed coupling element of proton translocation, coordinates conformational changes by linking discontinuous transmembrane helices between the ND5, ND4, and ND2 [57,58].
And in the Discussion they don't discuss whether or not a different set of salt bridge switches may coordinate conformational changes.
The loss of translocation by R88A suggests that both sides of the pore participate in coupling ATP hydrolysis with translocation through coordinated conformational changes between HD1 and HD2 on one side and HD1, the FeS and the Arch domain on the other side of the pore.
Chair-chair interconversion is a complicated process brought about by successive conformational changes within the molecule.
This raises a basic question: Does molecular recognition gain any advantage by such conformational changes?
