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In fact, retention of gene duplicates may be facilitated by coordinated reduction of expression levels, rendering both copies necessary to fulfill the biological role of the ancestral gene whereas creating redundancy at the level of their molecular function (Qian et al. 2010).
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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Coordinated reduction of transcription of genes involved in amino acid catabolism suggests redirection of amino acids from catabolic pathways to protein biosynthesis.
Robert Zoellick, the Bush administration's trade representative, has called for coordinated reductions of American and European subsidy payments, the equivalent of mutual arms reduction.
A prominent theme is a strong global suppression of metabolic rate, involving a regulated and coordinated reduction in all metabolic processes [3,11].
Calls by Mr. Marchionne for a coordinated, industrywide reduction of factory capacity have not led to any action.
The move followed a similar action earlier this week by the French central bank, which said its cut was the first step in a round of coordinated reductions by the major industrial countries.
Maximal reduction of AKT phosphorylation (69% reduction in MESO924 and 61% in MESO428) was achieved by coordinated inhibition of EGFR, MET, and AXL, compared with DMSO and empty vector treatment controls.
In the submerged trachea, particles were transported cranially by coordinated beating of ciliated cells.
This transition seems to be regulated by coordinated action of protein kinases and phosphatases.
Plants respond to diverse environmental cues including microbial perturbations by coordinated regulation of thousands of genes.
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