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Recent studies have established that the intrinsic DNA methylation patterns in both plants and animals are faithfully maintained and perpetuated by coordinated function of at least two classes of DNA methyltransferases (maintenance and de novo), together with active demethylases, i.e., the 5-methylcytosine DNA glycosylases [ 48, 49].
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Therefore, GSC self-renewal is controlled by coordinated functions of niche-initiated signaling pathways and intrinsic factors.
The conversion of ammonia into urea by the human liver requires the coordinated function of the 6 enzymes and 2 transporters of the urea cycle.
This adaptive response should involve a coordinated function of several genes and pathways, regulated by transcription factors with a broad cellular role.
The current model for the coordinated function of the ESCRT complexes proposes that ESCRT-0, formed by Vps27p/HRS and Hse-1, is dedicated to the formation of cargoes of ubiquitylated proteins at the endosomal membrane.
This indicates a coordinated function of ISP1 and ISP3 in their expression.
The coordinated function of the MVB pathway and autophagy is required to enter quiescence upon starvation.
These processes require the coordinated function of complex multi-component molecular machineries for example [ 4– 9].
During aging, the coordinated function of elements within the reproductive neuroendocrine axis degrades.
To the best of our knowledge this is the largest genomic study establishing the coordinated function of C14 miRNAs.
Proliferation of mammalian cells requires the coordinated function of many proteins to accurately divide a cell into two daughter cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com