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Made leaner by conversion to a limited company, Airbus can hope to catch up further on Boeing.
The targeting of drugs for a specific site in the body by conversion to a prodrug is plausible when the physicochemical properties of the parent drug and prodrug are optimal for the target.
A Pummerer-type thioglycosylation reaction of 24 with a persilylated uracil derivative, followed by conversion to a cytosine derivative and deprotection, gave a racemic mixture of the ring-expanded 4′-thio-apio-nucleoside derivative 4 in good yield.
INTERVENTION: Children were randomized after appendectomy either to a 10-day course of a combination of i.v. ampicillin, gentamicin sulfate, and clindamycin (n = 10); or to a short course of a combination of i.v. ampicillin, gentamicin, and clindamycin, followed by conversion to a combination of p.o. amoxicillin and clavulanate potassium plus metronidazole (n = 16).
Data supporting the early increase in age of subducted oceanic crust during Franciscan history was first presented Murchey and Blake (1993), who proposed that this age pattern resulted from subduction of an active spreading ridge at ca. 170, followed by conversion to a transform margin until initiation of new subduction at ca. 150.
The calculated partial correlation coefficients were then normalized by conversion to a z-statistic using the Fisher's transformation.
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These models of the PIP2−channel complexes were refined by conversion to an atomistic representation followed by molecular dynamics simulation in a lipid bilayer.
This approach is based on the principles of narcotic withdrawal where withdrawal syndrome is managed by conversion to an orally active drug with a longer half-life (such as methadone or diazepam) that has a more steady state serum concentration, more readily facilitating a slow tapering of the drug and minimising the severity of withdrawal symptoms or even development of the withdrawal syndrome.
Cyanide is detoxicated in the body by conversion to thiocyanate, a sulphurcontaining compound with goitrogenic properties.
Indeed, previous researchers have suggested CO2 entering cells can become trapped intracellularly by conversion to HCO3− through a P-ETC associated pathway [29].
It is established that these components are sufficient to yield molybdopterin, identified by conversion to its characteristic products, Form A, Form B, and dicarboxamidomethylmolybdopterin.
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