Sentence examples for by controlling the activity from inspiring English sources

Scientists knew that REST played a key role in fetal brain development by controlling the activity of certain genes, but they thought it was absent in adult brains.

Phorbol esters, via binding to the PKC C1 domains, cause major effects on mitogenesis by controlling the activity of cyclin cdk complexes and the expression of cdk inhibitors.

Identification of Abd-B target genes revealed that Abd-B mediates its effects by controlling the activity of the sevenless ligand Boss via its direct targets Src42A and Sec63.

A complex set of allosteric feedback loops are thought to allow the four dNTP pools to achieve the desired concentrations and stoichiometry, in large part by controlling the activity of RNR towards each of its substrates.

Furthermore, by controlling the activity of both p53 and Rb, PIASy regulates Ras-induced senescence and apoptosis [ 42].

Our data suggest that SPAK regulates blood pressure by controlling the activity as well as expression of the renal sodium cotransporters NCC and NKCC2.

Many studies suggest that we may mimic the beneficial effects of calorie restriction by controlling the activities of some proteins involved in the aging process.

Many human cancers have mutations in a gene that encodes a protein called Ras, which promotes cell growth and division by controlling the activities of other proteins.

Importantly, PKC phosphorylation of a serine residue in this region modulates membrane mechanical properties by controlling the activities of both the FERM and the spectrin-actin-binding domain [ 16].

GPX4 has also been shown to play a regulatory role in arachidonic and linoleic metabolism by controlling the activities of 12-LOX and cycloxygenase (COX) (Huang et al., 1999).

Thus, we suggest that HDAC inhibitors are involved indirectly in Met and CXCR4 induction by controlling the activities of transcription factors with different mechanisms that possibly depended on carcinoma cell aggressiveness.