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A classic McDonald Kreitman (MK) test [5] was conducted by contrasting patterns of polymorphisms and divergence.
We studied eight matching species pairs that are characterized by contrasting patterns of dichromatism, comprising seven avian families (Additional file 1: Table S1).
We did so by contrasting patterns of polymorphism at candidate genes with a set of control gene fragments and a coalescent framework where simple demographic models were fitted to the control data.
In this issue, a paper by Rapp et al. [ 3] tackles the question of how broad-scale gene expression can change with domestication by contrasting patterns of gene expression in developing fiber cells from domesticated and wild cotton.
By contrasting patterns of sequence divergence between genes in high- and low-recombination regions of the genome and by analyzing genes with and without evidence of positive selection separately, we obtained evidence that the efficacy of both positive and negative selection is higher in regions with more frequent recombination, as predicted by the HRI theory (fig. 3 and table 4).
This implies that the inference of an adaptive value of parallel divergent traits by Derome et al. [ 20] and St-Cyr et al. [ 22] is not invalidated by contrasting patterns of regulatory divergence for a given candidate gene in juvenile fish and vice versa.
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We did this by directly contrasting patterns of activation in observers presented with displays comprising signs in BSL and spoken words.
The painter Christina Quarles depicts a surreal scene in which slumbering figures occupy parallel planes of existence, delineated by contrasting patterns.
As could be expected, this procedure selects a subset of amplified (respectively deleted) clones that have a variety of deletion (respectively amplification) rates, whereas our modeling approach is aimed at refining this characterization, by focusing on highlighting clones with contrasting patterns of amplification and deletion.
As typically done for univariate analyses, we resolved this problem by contrasting pattern similarity estimates between two conditions of interest (i.e., the difference between same-room and different-room similarity).
By contrast, patterns of alterations in the commonly reported functional parameter Ktrans were inconsistent.
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