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Discussion This is the first study to focus on the use of a loading dose of vancomycin followed by continuous infusion in critical ill children.
The fast metabolism of this drug enables it to be used for long periods of anaesthesia by continuous infusion in rodents and maintain a fairly rapid recovery following the last administration, but it has to be administered intravenously (i.v). in rodents [38].
Two-thirds of the ICUs monitored vancomycin serum levels and administered it by continuous infusion in 86% of cases.
To our knowledge, this study is the first one designed to investigate the pharmacokinetics of ceftazidime, administered by continuous infusion, in critically ill patients undergoing CVVHDF.
Studies also have demonstrated the efficacy of carbapenem antibiotics administered by continuous infusion in critically ill patients and in patients with resistant pathogens.
There is a relatively wide margin of safety when midazolam is administered by continuous infusion in the ICU setting, where facilities are available for appropriate monitoring [ 40].
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In 12 critically ill patients with VAP (median weight = 80 kg), linezolid (loading dose = 600 mg followed by 1200 mg/day by continuous infusion) resulted in a linezolid alveolar diffusion of 100% and concentrations exceeding almost twice the susceptibility breakpoint for Staphylococcus aureus (4 mg/l) in both serum and epithelial lining fluid for 100% of the time [22 ▪].
The genes that were up-regulated by continuous infusion of GH in at least one of the in vivo models in a statistically significant manner are indicated with a #.
We administered intra-arterial chemoradiotherapy by continuous infusion of carboplatin in 65 cases from January 1993 to July 2002.
The use of IV boluses that were not followed by continuous infusion also is reported in 30% of procedures.
To assess the bispectral index (BIS) and the hemodynamic effects of propofol administered by continuous infusion at different rates in calves.
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