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The alumina-supported platinum catalyst was chirally modified by continuous dosing of small amounts of cinchonidine (CD) to the reactor feed containing EP and hydrogen dissolved in acetic acid.
Emissions in the naturally ventilated housing are determined by continuous dosing of two artificial tracers (sulphur hexafluoride SF6, trifluoromethylsulphur pentafluoride SF5CF3) and their real-time detection in the ppt range with an optimized GC-ECD method.
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Indeed, from published phase I studies, it appears that single-dose regimens were replaced by more frequent administration schedules, and continuous dosing of orally available drugs may be the way forward.
At the 800-mg dose, metabolic response rate on day 15 (after 2 weekly doses of cetuximab and 1 week of continuous dosing of brivanib alaninate) was 53% by EORTC criteria and 43% by repeatability threshold.
Alternatively, a continuous dosing of 37.5 mg may be applied.
Continuous doses of NSAIDs were permitted.
Dose escalation was stopped at 1500 mg BID continuous dosing without reaching the MTD of telatinib.
Telatinib is safe and well tolerated up to a dose of 1500 mg BID continuous dosing.
Telatinib is safe and well tolerated up to doses of 1500 mg BID continuous dosing.
Two patients had dose reduction because of both toxicity and continuous dosing (time to dose reduction 1.4 and 4.2 months).
Five milliliters of 0.375 % ropivacaine was administered through the epidural catheter, and continuous dosing with 1.5 % ropivacaine was provided by epidural infusion.
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