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By containing a functional, chromosomally-integrated copy of the bacterial gpt gene, AS52 cells a facile system for evaluating the mutagenic properties of genotoxicants.
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Plasmids containing a functional variable light and heavy chain were selected by colony PCR using primers 23, 50 and 53.
Transfection experiments, using a COUP-TFII promoter containing a functional cAMP responsive element, suggest a direct transcriptional activation by cAMP.
Therefore, every bacterium containing a functional luxS gene is capable of producing an activity detected by an AI-2-specific V. harveyi reporter strain (Federle and Bassler 2003).
The 165-bp region removed by the zyg-2 (b10ts ) premature stop is not predicted to contain a functional domain.
The dopamine D2 receptor promoter contains a functional retinoic acid response element and is regulated by retinoic acid [ 9, 10].
Thus, the PIK3CA promoter contains a functional NF-κB binding site and can be activated by NF-κB NF-κB
The fragment encompassing ORF5 contains a functional plasmid replicon.
These chimeric constructs therefore contain a functional MMP cleavage site.
This loop may contain a functional motif that contributes to the functional specificity of LGI1.
In future the scaffold could more closely mimic the complexity of ECM by containing several functional monomers including different cell adhesion motifs e.g., PHSRN or protease remodelling sites.
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