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Non-uniqueness can be avoided by constraining the model as much as possible to measurements and/or data from literature, although they cannot be considered always as fixed values and should be considered as stochastic variables instead.
Different levels of MI were tested by constraining the model parameters step by step.
A default parameter set was developed, partly informed by the literature and partly by constraining the model to mimic reported behavioural features of the system.
However, by constraining the model using measured NO X concentrations, and effectively isolating the chemical scheme we have shown the model to be able to predict the hourly NO2 very well close to roads, despite its simplicity.
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Stochastic control was applied in property modelling by constraining the modelled properties with well body volumes and inversion products (porosity and permeability maps).
Degeneracy can be reduced by further constraining the model using known regulatory interactions [ 17], metabolite concentrations [ 18] or thermodynamic laws [ 19].
The clinical models are defined by constraining the reference model [ 31].
We corrected for ascertainment by constraining the genetic model parameters for Sz to constant values: point estimates (h =.81, c =.11, e =.08) from a recent meta-analysis (37) and the liability threshold to give a prevalence consistent with a lifetime risk of 1%.
This technique prevents the tendency to overfit a model by constraining the effect that the variables will have in the model.
Environmental conditions are applied to the model by constraining the exchange fluxes of extracellular metabolites.
In silico simulations of single gene knock-out growth were carried out for each of the genes in the model by constraining the flux of all corresponding reactions to zero and then estimating the maximal biomass flux using FBA.
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