Sentence examples for by considering the mutation from inspiring English sources
Moghadas derived optimal treatment levels for minimising the impact of drug resistance by considering the mutation process in more detail, but did not account for prophylaxis [42].
Genome doubling (GD) was determined from the comparison of the sequencing of the grade II and the grade IV regions and by considering the mutations located in the portion of the genome where a clear doubling of the number of alleles was detected, see supplementary Information, available at Annals of Oncology online, for details.
The robustness is crucial for the potent inhibitor design by considering the frequent mutation of the virus.
The different loci were weighted considering the mutation rates published by Kayser et al. [ 11].
This can be seen by considering the mean number of mutations produced by the resistant cell population by time t, that is, approximately.
To provide further insight into the underlying mutational processes, we incorporated the sequence context in which mutations occurred by considering the bases immediately 5′ and 3′ to each mutated base, giving 96 possible trinucleotide contexts for a mutation.
To provide greater depth of insight into the operative mutational processes, we incorporated the sequence context in which mutations occurred, by considering the bases immediately 5′ and 3′ to each mutated base.
ML was determined for each tissue target by considering the presence and clonality of LOH mutations and the presence of MSI at each genomic locus.
We begin by considering the initial rate of spread of sterile mutations (the upslope, sup).
Accumulation of replication-dependent mutations is best understood by considering the pedigree of all cells that descend from the primordial progenitor (Fig. 2a cc).
The relative efficiency of natural selection in preventing the accumulation of deleterious mutations is often quantified by considering the relative rates of fixed nonsynonymous and synonymous substitutions in protein-coding genes [ 20, 33].
