Sentence examples for by conformational variability of from inspiring English sources

Thus, the reduction in affinity caused by conformational variability of the protein target can be partially or wholly offset by compensatory binding to the up conformation.

A recent study by Thornton's group reveals that pockets binding the same ligand show greater variation in their shapes than can be accounted for by the conformational variability of the ligand, which suggests that the geometrical complementarity is not sufficient to drive molecular recognition process [17].

Interest in dynamics has been stimulated by conformational variability among crystal forms and evidence suggesting that the functional monomer undergoes a conformational change on receptor binding.

A common theme that has emerged from these studies is the dramatic structural flexibility of these holoenzymes despite their strong overall sequence conservation, evidenced both by the extensive diversity in the architectures of the holoenzymes and by the extensive conformational variability of their domains and subunits.

The MaxOcc approach was used to characterize the conformational variability of MMP-1 by rigidly attaching a paramagnetic tag to the catalytic domain.

The extensive conformational variability of free calmodulin is testified by the sizable reduction of the RDC-derived anisotropy tensor of the C-terminal domain with respect to the anisotropy tensor of the N-terminal domain, where a paramagnetic lanthanide ion is introduced.

To reduce noise and binding site definition artifacts associated with increased conformational variability of individual residues, the contact strength vector components were multiplied by a factor ranging from 0 to 1 and inversely proportional to the observed conformational variability of the corresponding residue in the Pocketome ensemble.

Conformational variability of the IVth domain, postulated to be responsible for the catalytic function of the enzyme has been studied by normal mode analysis (NMA) and the conformational features responsible for domain movement in the 'hinge region' analyzed in detail.

The NMR spectra obtained are discussed in terms of the conformational variability of the active center of the Ras nucleotide complex.

However, computational evidence suggests that the conformational variability of Fcs plays an important role in receptor recognition.

However, rotation about the CDC20-MCC assembly and conformational variability of APC/C modulate UBE2C-catalyzed ubiquitination of MCC's CDC20 molecule.