Sentence examples for by conformational changes that from inspiring English sources

So that ions flow only when needed, the pathway through an ion channel can be opened and closed by conformational changes that displace an obstruction called a gate.

For kinases, allosteric mechanisms described to date include alteration of protein kinase conformation blocking productive ATP binding which appear 'ATP competitive' or blocking kinase activation by conformational changes that are 'ATP non-competitive'.

Its O2 reactivity is regulated by conformational changes that are triggered by shifts in protonation states.

The primary DD2 binding pocket, ∼15 Å from the active site, is formed by conformational changes that occur only in the partially disordered monomer.

Additionally, substrate binding may be prevented by conformational changes that occlude the substrate binding pocket, such as movement of loop residues 14 27 in KSHV Pr.

Analyses of HIV-1 RT crystallographic indicated that the polymerase activity can be significantly influenced by conformational changes that occur in an allosteric site known as NNRTI binding pocket (NNRTI-BP) [ 7, 15].

Like every enzymatic reaction, its ability to catalyse is made possible by the conformational changes that take place during the reaction.

Notably, Tyr phosphorylation activates Cbl by inducing conformational changes that eliminate autoinhibition.

One possibility is that the Ssn6-Tup1 complex switches from a repressive to an activating state upon galactose induction by undergoing conformational changes that modify its affinity for various partners.

Numerous studies indicate that ESCRT-III subunits are activated by intramolecular conformational changes that promote protein-protein interactions (Henne et al., 2012; Lata et al., 2008a; Saksena et al., 2009; Schuh et al., 2015; Shen et al., 2014), but the structural basis for this is obscure.

We demonstrate our method by measuring the conformational changes that occur upon ligand binding with three well-characterized proteins labeled at lysine residues: calmodulin (CaM), maltose-binding protein (MBP), and dihydrofolate reductase (DHFR).