Sentence examples for by conformational changes of from inspiring English sources

Another of the novel inhibitors achieves improved selectivity through an unexpected hydrogen bond with Gln217, with a unique bent conformation in FVIIa/TF accompanied by conformational changes of the inhibitor and the protein.

Zhang, F. et al. Two-dimensional kinetics regulation of αLβ2-ICAM-1 interaction by conformational changes of the αL-inserted domain.

This cavity seems to be regulated by conformational changes of the α1-helix itself during the dynamics.

The efficiency of energy transfer between the donor and acceptor fluorescent proteins depends on the relative distance and orientation between them, which become altered by conformational changes of a fused sensory protein caused by a cellular event.

Entry of SARS-CoV into a target cell is initiated by binding of the S1 domain of spike protein to a receptor, followed by conformational changes of the spike protein S2 domain, resulting in the formation of a six-helix bundle by the heptad-repeat (HR1 and HR2) regions.

PLCγ1 (phospholipase C gamma 1) can interact with activated IR in a SH2 domain-independent manner, which may be mediated by conformational changes of IR (Kwon et al., 2003).

Ca2+ release from the RyR1 (predominant isoform in skeletal muscle) instead is triggered by conformational change of the voltage sensor in the DHPR upon depolarization of the T tubule (referred to as depolarization-induced Ca2+ release, DICR) [6], [7].

Phosphorylated BIMEL was dissociated from MCL1 and interacted with BAX, followed by conformational change of BAX.

EXO1 can possibly process 5′ flaps by tracking, threading and non-threading mediated by either DNA configuration or by conformational change of the EXO1 enzyme [ 8].

Protein and peptide aggregation into mature amyloid fibrils is a multistep process initiated by conformational changes with samplings of prefibrillar intermediate amyloidogenic aggregates (PIAA), such as oligomers, protofibrils, pores, amylospheroids, and short fibrils [1].

On the contrary, in spite of the competition observed with AP33, mutations inside the AP33 epitope did not affect e20 binding, showing that the e20 conformational epitope does not contain the linear AP33 epitope, and that the observed competition may be mediated by steric hindrance, or by induced conformational changes of the antigen.