Sentence examples for by conditional inactivation of from inspiring English sources
Wang, Q., Strong, J. & Killeen, N. Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene.
This apparent cooperation of Brca1 and p53 in inherited breast and ovarian cancer in humans and in mammary tumor development in mice led us to create a mouse model of ovarian cancer by conditional inactivation of Brca1 and p53 in the ovarian epithelium.
The expression of genes that are part of the PI3K-AKT-mTORC1 pathways was not significantly affected by conditional inactivation of LHX8 in oocytes by both quantitative PCR and RNA-seq (Fig. 2 and Additional file 5: Table S1).
By conditional inactivation of the Kif3a gene, encoding a subunit of the kinesin-2 complex that is essential for cilia formation fibrosis, lipomatosis and cyst formation was observed in pancreatic tissue [ 144, 145].
Brg1's role in lens fiber cell differentiation is supported by ectopic expression of the dnBrg1 transgene in lens and by conditional inactivation of Brg1 in the presumptive lens ectoderm.
In this assay, we regulated the activity of a particular centromere (CEN3); CEN3 was displaced from the spindle and other centromeres by conditional inactivation via transcription from the adjacently inserted GAL1-10 promoter [19].
In the present study, we sought to extend these previous observations by testing whether conditional inactivation of Brca1 and p53 in the ovarian surface epithelium in situ is sufficient to establish an autochthonous mouse model of BRCA1-associated invasive EOC.
Since Lhx1 null mice exhibit a headless phenotype, whether mouse Lhx1 functions during early OV development or not must be clarified by future studies using conditional inactivation of Lhx1.
Consistent with the data on BMPs produced by the early embryonic eye, conditional inactivation of the type I BMP receptors Bmpr1a and Acvr1 in the PLE also disrupted the early stages of lens development and demonstrated that BMP receptor signaling also regulates both cell survival and proliferation during lens placode formation (Rajagopal et al., 2009).
Recent work by Borowiak and colleagues has shown that conditional inactivation of c-met using a ubiquitously expressed alpha/beta interferon-inducible promoter resulted in suppressed Erk1/2 activation and defective exit from quiescence in regenerating mouse liver [7].
Several studies have uncovered an inhibitory role of Wnt/β-catenin signaling in vertebrate heart specification, which is most dramatically revealed by the formation of ectopic hearts after conditional inactivation of β-catenin in the definitive endoderm of the mouse embryo [ 67].
