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This inverse pattern further suggests that NKX3.1 is a key driver of luminal cell differentiation, whereas loss of NKX3.1 would allow luminal cells to dedifferentiate into a state with higher proliferative capacity thus making them more vulnerable to the acquisition of additional oncogenic events perhaps augmented by concurrent defects in DNA repair.
Therefore, the data give insights about the requirement of the NKX3.1 as a key driver of luminal cell differentiation, its loss allows luminal cells to dedifferentiate into a state with higher proliferative capacity leading to the increased genetic heterogenity, perhaps augmented by concurrent defects in DNA damage repair pathways.
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Patients with a concurrent defect in aldosterone biosynthesis also present life-threatening conditions which usually appear at 1 4 weeks of age in both sexes.
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Technology adoption only improves productivity if it is accompanied by concurrent changes in the way work is done.
Denaturation of the intermediate was monitored by concurrent changes in fluorescence and circular dichroism signals.
"The Hypothermic Effect of Late Evening Melatonin Does Not Block the Phase Delay Induced by Concurrent Bright Light in Human Subjects " Neuroscience Letters 232 (1997): 57-61.
Resonant Cavities: By making point defects in a photonic crystal, light can be localized, trapped in the defect.
These mutations cause chromosome segregation defects similar to those provoked by defects in condensation.
These cell migration defects were potentially caused by defects in cell adhesion mechanisms.
However, this interaction was not impaired by concurrent overexpression of TRIM28 in these cells, suggesting that TRIM28 is unable to disrupt TRIM24-SPOP interaction.
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