These organizations have been favoured by the concomitant reduction of direct public intervention (due to spending review) and the effect of the economic crisis on the business system.
Addition of DOTA derivative was often followed by a concomitant reduction of binding affinity, most probably due to the steric hindrance of such residue, as exemplified with somatostatin analogs [29].
The oxidation of two substrate molecules is accompanied by the concomitant reduction of hydrogen peroxide to water.
Located inside the mitochondria, LDH-C is able to directly oxidize lactate by a concomitant reduction of NAD+ to NADH and donating two electrons to the ETC.
The decrease of TOPO I was accompanied by a concomitant reduction of TOPO IIα expression, which was particularly pronounced (>4-fold) in 6/7 colorectal tumors and 8/10 ovarian tumors (Fig. 3e).
Both effects can be explained by a concomitant reduction of the extracellular space (ECS): During cell swelling, increased tissue resistance enhances the voltage across neuronal membranes (Andrew et al., 1989), while also elevating the concentration of ambient neurotransmitter molecules in the vicinity of ligand-gated ion channels (Huang et al., 1997).
The oxidation of four substrate molecules by laccases goes along with the concomitant reduction of one equivalent of molecular oxygen to water that is the sole by-product of the reaction.
In melanoma xenografts, ETBR blockade by ETBR antagonist results in a concomitant reduction of tumor growth, angiogenesis, HIF-1α, and HIF-2α expression, and an increase in PHD2 levels.
Laccases (benzenediol: oxygen oxidoreductase, EC 1.10.3.2) are multi-copper oxidases able to oxidize various phenolic compounds by one electron transfer with the concomitant reduction of oxygen to water [ 11, 12].
As shown, a reduction of Pttg1 mRNA levels (by 90%, data not shown) without a concomitant reduction of Pttg2 did not result in an increase in the number of dead cells.
