Sentence examples for by concomitant inactivation of from inspiring English sources
Brca1 inactivation in primary cultures of murine OSE cells led to a suppression of proliferation that could be rescued by concomitant inactivation of p53 and/or Rb.
Although Ink4a expression is clearly deregulated in these MEFs, Arf plays a more prominent role in senescence in mouse cells and in some cases the effects of the PcG knockout can be alleviated by concomitant inactivation of Arf [24], [60], [61].
Furthermore, cancer cell death induced by concomitant inactivation of Rb and TSC2 is mediated by increased cellular stress, including oxidative stress.
Furthermore, the maintenance of rho+ mtDNA in pif1Δ cells is synergistically destabilized by concomitant inactivation of the NTG1 gene, which encodes a nuclear and mitochondrial N-glycosylase/lyase specific for certain oxidatively modified bases (O'Rourke et al. 2002).
In mice in which Brca1 was inactivated in the mammary epithelium, the latency of tumor formation could be shortened by the concomitant inactivation of the p53 tumor suppressor gene [30], [31].
(Eqn. 9) PG nucleation by fully active ATG9 with concomitant inactivation of ATG9: where k nu is a rate constant.
(Eqn. 15) Dissociation of ATG9-WIPI1/2-PtdIns 3,5 P2: for I = 0,…, n and where k dis is the same rate constant in Reaction 8. (Eqn. 16) PG nucleation by fully active ATG9 with concomitant inactivation of ATG9: where k nu is the same rate constant in Reaction 9. (Eqn. 17) Recruitment of enzyme X into a PG in a zero-order (saturated) process: where k flux is the constant rate of recruitment.
The phosphorylation and concomitant inactivation of 4EBP-1 by mTOR leads to disaggregation of 4EBP-1 from eIF4F, a translation initiation factor [ 22].
Concomitant inactivation of Chk2 and p53 in breast cancer has been recorded by others [59], and the finding that a somatic mutation may generate a "growth advantage" in tumor cells already harboring a germline CHEK2 mutation may not implicate an effect on drug sensitivity in tumors not yet exposed to cytotoxic compounds.
Moreover, nucleos(t)ide analog (NUC) therapy restores HBV-specific T cells function58 with concomitant inactivation of NK functions59.
The concomitant inactivation of Ink4 inhibitors in the Cdk4(R/R) background prevented the effect of p21/p27 ablation in the number of neurospheres and, to a lesser extent, in their size (Figures 6a c).
