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Targeted modulation of p75 NTR) provides a strategy for preventing degeneration without promoting TrkA-mediated deleterious effects, and targeted activation of TrkB might achieve more favorable neurotrophic effects than those achieved by concomitant activation of p75 NTR) and TrkB.
Recently, we established that expression from the FLT1 promoter could be modulated in response to genotoxic stress by concomitant activation of the p53 tumor suppressor and Estrogen Receptors (ERs) [17].
WRC activation is achieved by concomitant activation of Arf and Rac GTPase at the membrane (Koronakis et al., 2011).
EGF agonists are mitogenic in the mammary fat pad of young females [ 49], and probably work by concomitant activation of EGF receptor and ErbB-2.
However, a recruitment of memory processes in low-arousal emotions is indicated by concomitant activation of hippocampal and parahippocampal regions, particularly in the right hemisphere.
This is prevented in budding yeast by concomitant activation of the Cdc14 phosphatase, which, helped by cyclin proteolysis and Cdk downregulation, leads to dephosphorylation of Sli15INCENP.
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Our finding that induction of DNA damage by CDT is accompanied by the concomitant activation of survival signals suggests that chronic infection with CDT producing bacteria may promote genomic instability and favour malignant transformation.
The use of NO-Cbl to inhibit survival signaling may enhance drug efficacy by preventing concomitant activation of NF-κB or AKT.
Disseminated intravascular coagulation (DIC) is characterized by the concomitant activation of coagulofibrinolytic disorders and systemic inflammation associated with endothelial dysfunction-induced microvascular permeability.
The accumulation of catechin is preceded by a concomitant activation of genes in the phenylpropanoid pathway (PAL, C4H and 4CL) and of genes in the epicatechin and catechin biosynthetic pathways upon wounding and H. annosum attack.
Cells from this patient as well as PEL cell lines showed that the pro-apoptotic effect of this combination is mediated by a concomitant activation of tumor necrosis factor-related apoptosis-inducing ligand and nuclear factor kappa B (NF-κB) inhibition.
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by concomitant stimulation of
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