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In general terms, the metabolic adaptation from oxidative towards respiro-fermentative growth was accompanied by complex changes of carbon flux throughout the whole central carbon metabolism, as previously described in other yeasts (S. cerevisiae [ 21, 22], P. anomala [ 23, 24]).
This decline is accompanied by complex changes of the chromatin structure among them changes in histone modifications and DNA methylation which both affect transcription of a tissue-specific subset of genes.
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Transcriptome plasticity is conferred not only by altering the concentration levels of transcripts, but also by complex changes in the architecture of transcripts (splice isoforms, editing, transcription start and termination sites).
Our findings indicate that ASD is characterised by complex changes in GM developmental trajectories of several brain regions.
Although the predicted weight loss appeared to be almost linear throughout the period of starvation, these linear tracks were underpinned by a complex change in the pattern of utilisation of different body compartments.
Interestingly, thermal annealing followed by addition of CaCl2 caused complex changes in the observed agent relaxivity (Table 1 ).
It is likely that more complex changes can be triggered by selection conditions.
Complex changes in miRNA expression suggest a potential role of miRNAs in antiviral responses by regulating immune-related genes.
The findings suggest the existence of a diffuse complex of changes, consisting of a gradual vascular widening followed by narrowing, with associated mural changes reflecting the atherosclerotic process.
The optical conductivity of the complexes changes due to the formation coordination of the complex.
Schizophrenia is characterized by complex gene expression changes.
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