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The vaccine treatment group showed a favourable result when subjected to analysis of the ORR which was denoted by complete response rates (CR) and partial rates (PR), compared with the corresponding control arm (OR 1.36, 95% CI 1.02 to 1.80, p=0.05).
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The higher chemotherapy sensitivity is reflected by higher pathologic complete response rates to a broad range of preoperative regimens and also by the greater benefit from adjuvant chemotherapy in general.
Adding aprepitant significantly improved acute complete response rates by 11 to 14% and delayed rates by 20%; overall, from days 1 to 5, the improvement was 19 to 20%.
In addition, we reviewed an intriguing study looking at pathologic complete response rates by anti-diabetic medication use.
Likewise, in the NSABP B-27 trial in which 2,411 patients were randomised to neoadjuvant adriamycin/cyclophosphamide (AC) versus the same treatment followed by sequential docetaxel, the complete response rate was 64% for the sequential, docetaxel-containing arm compared with 40% for the AC arm alone (P < 0.001), but no significant difference was seen in long-term survival [ 3, 4].
The parameter residual invasive tumor size (RITS) was significantly reduced by 43% (CT alone 27.4 mm vs. CT + Zol 15.5 mm; p = 0,006) and pathological complete response rate improved by 69% (CT alone 6.9% vs. CT + Zol 11.7%; p = 0.146), which, however, was not statistically significant.
The impact of studied variables on severe toxicity and complete response rate was analysed by logistic regression.
The complete response rate was not significantly affected by the number of hyperthermia treatments given per week.
The complete response rate was 17.5%.
Chemotherapy alone achieved a 75%% complete response rate.
Complete response rate and recurrence rate.
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