Sentence examples for by competition of binding from inspiring English sources

These mutants do not show a DN phenotype but were able to block toxicity when used in 10∶1 or 100∶1 ratios (mutant∶wt) probably by competition of binding with toxin receptors.

The specificity of apotransferrin nanoparticles in cellular interaction and entry was assessed by competition of nanoparticles binding in both the presence and absence of mouse anti-human transferrin receptor monoclonal antibody (1 µg/0.5 million cells).

Furthermore, blocking of the cAMP signaling was investigated by competition of receptor binding by the calcitonin receptor antagonist 8-32sCT.

The interaction between a single cationic amine and anionic phosphate groups of nucleic acids is relatively week and is further weakened by competition of salt binding under biological conditions.

In this study, we demonstrated for the first time that A β42O induces the depletion of surface β1-integrin via its direct binding to low-intermediate activation conformers of β1-integrin, as detected by competition of A β42O binding to neurons and HT22 cells with the β1-integrin activating antibody (HUTS-4) or MnCl2, both of which induce high conformational activation of β1-integrin.

We further identified that BBR may most likely bind Smo at the same pocket with cyclopamine, as reflected by competition of BBR for binding to Smo with SAG and BODIPY-cyclopamine.

In 1995, Gaubatz et al. [ 28] showed that AP2 acts as an inhibitor of Myc-mediated transactivation, a function that is mediated both by competition of AP2 with binding of Myc or Max and by direct protein-protein interaction of AP2 with the BR/HLH/LZ domain of the Myc protein.

We developed a novel combinatorial approach that combines the local optimization of cohesiveness based on weighted protein interaction data and the competition of binding interfaces by adapted integration of domain interaction data.

6) The authors show that importin beta inhibits NPC passage of Nup188 and Nup192, and explain the effect by competition of the two species for FG binding sites.

Thus, one way to consider the importance of the Btk allosteric binding site for IP6 is that it is needed to prevent down-regulation by competition of IP6 for PIP3 at the PIP3 binding site.

This mechanism is enabled by the competition of CCR7 binding between CCL19 and CCL21, together with the differential ability of CCL19 and CCL21 for desensitizing CCR7 and the unique superimposed chemokine field profiles.