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The authors suggested that this might be caused by compensatory changes in the sensitivity of amine receptors or in the efficiency of amine uptake in adults, that resulted from increased amine release during embryonic or larval life.
Fourth, developmental compensation (or canalization) in early life whereby genetically-determined alterations in CRP might be buffered by compensatory changes in other systems may compromise the validity of the Mendelian randomisation approach [46].
The failure to observe functionality in some of our asymmetric simulations does not necessarily indicate that the parameters in question must be symmetrical in order for the network to function, as it might be possible to restore functionality by compensatory changes in other parameters in the network.
These data confirm specificity of the siRNA used to knock-down endogenous ADAMTS-12 mRNA levels in EVT cultures, and also demonstrate that a reduction in ADAMTS-12 expression is not accompanied by compensatory changes in the expression of other ADAMTS subtypes.
This acute knockdown approach revealed a dramatic wing hair differentiation phenotype that may be partially masked in nht mutants by compensatory changes in other TAFs.
This buffering is possibly explained by compensatory changes in post-transcriptional, translational or post-translational processes, or expression of other genes required for homeostasis of these elements.
Similar(46)
Our result suggests that the frame-shifting effects of complex ASEs are rescued by the compensatory changes in the flanking exons, thus leaving the downstream protein reading frames unaltered.
Another recent study demonstrated that a high carbohydrate and protein breakfast may prevent weight regain by reducing diet-induced compensatory changes in hunger, cravings and ghrelin suppression [ 47].
These results are in keeping with the observation of Fraser et al. (2002) that interacting proteins have similar evolutionary rates, which the authors explained by the occurrence of compensatory changes in interacting proteins.
Perturbations of membrane potential by ATP demand are inevitable and also require compensatory changes in the leak.
The cell wall inhibitor studies may point to a role of each TF in compensatory changes in response to cell wall defects caused by inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com