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By comparing the subset of genes upregulated in VMN to the entire transcriptome, we found 279 over-represented GO terms (complete list in Additional file 1: Table S1).

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GO analysis was conducted by comparing the subsets of interest (for example, genes uniquely differentially expressed in D. echolalia) against the total dataset of analysed genes (for example, genes in common among the three pure species) using FATIGO [ 31] http://babelomics.bioinfo.cipf.es/ using two-tailed tests, multiple test correction, and retaining any duplicates between lists.

These data were subsequently filtered to identify proteins with confirmed expression in type II epithelial cells (by comparing the unique protein subset to archived microarrays of mouse type II epithelial cells) and elevated expression in lung compared to other tissues.

The suitability of the applicability domain estimation is evaluated by comparing the model performance on the subsets of the screening data sets obtained by different thresholds for the applicability scores.

Calculations of differential enrichment at 37°C are clearly a composite, including cDNAs which were enriched at 37°C as well as those which were depleted at 30°C. Figure S4 separates out these two subsets by comparing the 37°C vs 30°C data to both the enrichment at 37°C and the depletion at 30°C.

To do this, after excluding sites that can be found by unique tags alone, we divide the set of sites rescued by ambiguous tags into two subsets by comparing the set with the benchmark.

Comparisons among independent QTL mapping projects usually attempt to determine if loci identified in each are the same by comparing the chromosomal position of a common subset of markers across different studies and/or indirectly by comparing each mapping population to a reference map [ 16].

Data accuracy for all three subsets was determined by comparing the extracted data with the gold standard data.

The validity of the self-reported waist circumference was assessed in a subset of 160 persons by comparing the self-measurements with measurements taken by a trained nurse.

The reproducibility of networks identified by discretization was examined by comparing the gene-pair lists for two randomly selected subsets of SAFHS.

By comparing the newer, updated scores with the older scores for this subset, we can evaluate the usefulness of Badapple.

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