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We next assessed changes in gene function by comparing the functional domain architecture of orthologous genes across species and we assessed changes in gene regulation by comparing their transcriptional profiles.
We evaluated our network construction method by comparing the functional representations of the derived networks with two other traditional construction methods.
Functional coverage of the unigenes was identified by comparing the functional distribution of the genes from fully sequenced A. thaliana genome.
Furthermore, by comparing the functional annotations of enzymes containing each domain family, Caetano-Anolles et al. attempted to reconstruct the phylogenetic relations of metabolic pathways (Caetano-Anolles and Caetano-Anolles 2003; Caetano-Anolles et al. 2009).
We evaluated our network construction method by comparing the functional representations of proteins in the derived networks with that from two traditional construction methods and our method achieved superior function analysis results.
By comparing the functional groups to which the dysregulated genes of bone and non-bone metastases belong, we found that the immune system may be essential in the bone specific metastasis of breast cancer.
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Therefore, this study endeavored to identify the trends in functional fitness decline by comparing the differences in the functional fitness of females in various age groups.
In addition to the demonstrated agreement with published human transcriptional data, we also addressed the clinical relevance of the present animal model by comparing the transcription-based functional profiles related to each experimental challenge with the functional signature derived from stable yet severe COPD patients when compared to healthy age-matched controls.
Firstly, short-term aftereffects were estimated at three levels (functional connectivity, local activity, and network properties) by comparing the resting-state functional magnetic resonance imaging datasets (9 min) acquired before and after each rTMS session.
The MRE-containing or MRE-free isoforms can then be identified by comparing the locations of functional MREs with alternative splicing (AS) sites.
An enrichment score was calculated by comparing the number of functional cis-elements measured by ChIP-chip (MacIsaac et al., 2006) within RDNPs and the number that would be within the elements by chance.
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