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The phylogeny of these genes could be examined by comparing sequences from different organisms.
By comparing sequences from related individuals we generated a consensus transcriptome.
In addition, by comparing sequences from all four meiotic products, we detected 21 putative GC events not associated with CO (Additional file 1 - Table S2).
Loss of heterozygosity (LOH) was analyzed by comparing sequences from the normal and the corresponding tumor DNA at the site of a variant.
In common bean, a set of 239 SNPs was first reported by comparing sequences from coding and noncoding regions and genomic DNA of a set of 10 diverse genotypes (Gaitan-Solis et al. 2008).
Nonetheless, the validation rate observed here was similar to the 85% reported for maize, where SNPs were detected by comparing sequences from two separate 454 runs, each interrogating a different inbred homozygous line [ 7].
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By comparing sequence from three or more vertebrate species, human sequences that are likely to be functional can be detected with improved sensitivity and specificity [ 13].
We screened canine insulinomas for mutations in SUR1 and Kir6.2 by comparing sequences obtained from insulinomas with those obtained from normal dogs.
Putative autapomorphic SNPs were identified by comparing sequences derived from a single cutthroat trout subspecies to the sequences of the other subspecies combined.
This finding was confirmed here by comparing sequences obtained from a larger panel of bird species (the extant vertebrate group closest to mammals).
By comparing sequences that evolved from a common ancestor, we can infer their phylogenetic relationships, discover sites under functional constraint, or even shed light on the function of individual sequence elements.
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by stitching sequences from
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