Sentence examples for by comparing expression profiles from inspiring English sources

To account for differences in starting material, RNA preparation, RNA quality and cDNA synthesis, adequate normalisation is frequently performed by comparing expression profiles of the genes of interest with those of constitutively expressed genes (= reference genes).

Here, by comparing expression profiles between SE and NE lineages, we observed that uncommitted progenitor cells, expressing stem cell markers, are present in the neural plate border/neural fold prior to neural tube closure.

Since deletion of Otx2 leads to a total loss of photoreceptors in the retina, by comparing expression profiles between the Otx2 CKO retina and control retina, we were able to identify photoreceptor-associated genes more clearly than by using other mutant retinas.

By comparing expression profiles with Drosophila melanogaster we also assessed which genes are well conserved within the Diptera versus those that are more recently evolved.

Some investigators have tried to identify a set of genes related to radiosensitivity by comparing expression profiles of radiosensitive and radioresistant tumours obtained as clinical samples before treatment using a cDNA microarray (Hanna et al, 2001; Kitahara et al, 2002).

Thus, this study aimed to correlate the use of potential biomarkers of PCa primary lesions with metastases by comparing expression profiles of normal prostate cells with those of clinically significant PCa cells from primary and from metastatic tumours.

Previous studies have identified genes important to the stem cell state by comparing expression profiling data from different stem cell populations such as ES cells, haematopoietic stem cells (HSCs) and neural stem cells [ 6, 18].

Cross-species analysis of gene regulation can be achieved by directly comparing expression profiles or by indirectly comparing co-expression clusters or networks [ 8].

Prior to comparing expression profiles, the consistency of transcriptome response was evaluated by comparing overall gene expression profiles across individuals.

These 2,631 common, differentially expressed genes were then further examined to assess the similarity of their EE- and TAM-elicited temporal expression profiles by comparing their expression profiles in order to assess similarity between the treatments.

From an entirely different angle, [ 21] provided an approach that screened genomic sequences against a database of putative regulatory motifs, evaluating the contribution of the occurrences of the motif on the gene expression by comparing the expression profiles of genes containing this motif against those that do not.