Within-groups effects were assessed by post-hoc tests comparing baseline levels with levels at other points in time, with results reported in detail in Table 2.
Factors significantly correlated with survival and neurological outcomes were investigated by comparing baseline characteristics and mediator blood levels.
We assessed the relationship between CDAI and APRs in the Consortium of Rheumatology Researchers of North America (CORRONA) registry by comparing baseline characteristics and one-year clinical outcomes of patients with active RA, grouped by baseline APR levels.
At 5 min after balloon inflation in the CS blood, levels of LCSB increased by 941% compared with baseline levels (n = 7; all P < 0.001), while in peripheral blood, levels of LCSB increased by 617% compared with baseline levels (n = 24; all P < 0.001).
Supplementation increased the serum level of α-tocopherol by 50% compared with baseline levels (12, 13).
At 12 h following the PCI procedure, in peripheral blood, levels of LCSB increased by 436% compared with baseline levels (n = 24; all P < 0.001; 95% confidence interval).
At 1 min following balloon inflation in the CS, levels of LCSB increased by 1,072% compared with baseline levels (n = 7; all P < 0.001), whereas in peripheral blood levels of LCSB increased by 579% compared with baseline levels (n = 24; all P < 0.001).
Values were always compared with baseline levels by using the nonparametric Wilcoxon matched pair test and Mann-Whitney U test.
Relative gene expression (using the delta delta Ct method [ 24]) was determined by comparing gene expression levels to baseline, where baseline for synoviocytes is equal to expression in synoviocytes cultured alone, and for injured cartilage cultured alone or in co-culture baseline is equal to control cartilage cultured alone or in co-culture respectively.
For instance, treatment with anastrozole for 15 weeks suppressed tissue estrone and estradiol levels by 83 and 89%, respectively, compared with baseline levels (Geisler et al, 2001), and letrozole treatment for 16 weeks suppressed pretreatment tumour levels of estrone and estradiol by 91 and 98%, respectively (Geisler et al, 2008).
