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To our knowledge, only a few papers have reported comparative proteome research in OS, including our previous data obtain by comparative proteomic analysis of patient sera [ 4- 8].
By comparative proteomic analysis of K562 and NB4 cells, we identified 25 membrane and 14 membrane-associated proteins.
We investigated two proteins out of those identified by comparative proteomic analysis that might be new possible functional biomarkers involved in the pathogenesis of SSc and ScGVHD disorders: PBP, which contributes to the extracellular fibrosis and FH which is essential for the vascular EC protection from the complement lysis [18], [19].
Nine of these have been confirmed by comparative proteomic analysis [ 7], whilst SUB0241 was not.
Annexins A1, A2, A4 and A11 were identified by comparative proteomic analysis to be overexpressed in colorectal cancer.
A total of 1028 differential protein spots have been detected in the four fractions by comparative proteomic analysis.
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Four differentially regulated oxidoreductases or related proteins (spots 7, 16, 26 and 27) were also picked up by the comparative proteomic analysis of P131 and Δ com1 strains.
In order to discover molecular biomarkers in radiation response we investigated the effects of X-radiation on radioresistant K562 cells by using a comparative proteomic analysis.
The aim of this study was to improve our understanding of the molecular basis of OA by performing a comparative proteomic analysis of articular chondrocytes derived from patients with OA and from disease-free individuals, using high-resolution mass spectrometry and label-free quantification.
The effect of the mutation was also investigated by carrying out a comparative proteomic analysis between wild-type and mutant plants at anthesis under the same conditions as described above.
On the other hand, Lin et al. (2014) showed that up-regulation of proteins involved in starch accumulation and down-regulation of ER proteins, PDIL 2 3 and BiP, were observed in the chalky tissue of notched-belly mutant appeared regardless of the environmental stress, employing a comparative proteomic analysis by iTRAQ (isobaric tags for relative and absolute quantification).
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