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The samples for analyses were prepared by combining samples from each of the triplicates of each treatment into a composite sample.
With little cost, imputation can boost power both by increasing SNP coverage and by combining samples from similar studies.
Following a multiethnic approach by combining samples from the CEU, CHB, JPT and YRI panels, we see again a power improvement for lower frequency alleles (in CEU).
We created source populations for each focal (analyzed) population by combining samples from the other two remaining populations.
Then the DNA was pooled by combining samples from one row or one column into a single pool, resulting in a total of 96 pools.
The published Hodgkinia genome was generated by combining samples from 10 wild-caught individuals of the cicada Diceroprocta semicincta (McCutcheon et al. 2009).
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We addressed this challenge by combining samples collected within the BIO-NMD consortium from four geographically dispersed clinical sites to identify protein markers associated with muscular dystrophy using an antibody bead array platform with 384 antibodies.
For Ile602Ser (rs5743618), analyses combining samples from this and the previous study by Wurfel et al. [14], did not enable the detection of consistent significant effects (results not shown).
Measurement by RIA of combined samples from each group showed that steroid receptor positive tumours had a mean figure of 14.8 ng g-1 tissue and steroid receptor negative 7.4 ng g-1.
Our study combines samples from heterogeneous sources.
44 45 The study by Montgomery et al 46 was excluded, as the data in this study were reported in a larger trial by Lepola et al. 22 The combined sample from eight studies consisted of 1237 subjects in the citalopram group and 788 in the placebo group (total=2025).
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