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Moreover, we elucidate how a single pathway can specify distinct physiological outcomes: by combining distinct temporal patterns of stimulation with proteomic profiling, we identify signaling programs that differentially respond to Ras dynamics, including a paracrine circuit that activates STAT3 only after persistent (>1 hr) Ras activation.
This makes comparison of different studies and collaboration by combining distinct datasets feasible.
Recognizing limitations in individual motif discovery tools [ 2, 3, 7], we sought to maximize detection of conservation by combining distinct methodologies.
By combining distinct features selected by FDAFSA and RTPFSGA, and SVM for classification of promoter and non-promoter sequences, we developed PromoBot, as an alternative technique for promoter identification.
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By connecting people in different areas and departments, engineers set the stage for combining distinct perspectives into novel, useful ideas.
Sophisticated molecular architectures can be produced with the layer-by-layer (LbL) method, which may combine distinct materials on the same film.
The Yale team made its discovery by combining the distinct properties of two material components.
Therefore, several attempts are made to develop biphasic composite constructs for bone-cartilage engineering by combining two distinct scaffold materials.
This paper analytically studies the effect of hierarchy on the stiffness and strength of self-similar and hybrid type lattices, made by combining two distinct variants of topologies, governed by the bending and stretching dominated architectures.
The ancient Chinese created the Chinese expression for "crisis" by combining two distinct characters: the symbols for danger and opportunity.
With regards to the second issue, although early drugs were discovered serendipitously, multi-target compounds are now rationally designed, typically by combining two distinct frameworks into a single chemical entity [38 40], starting from compounds with the desired activity towards the targets of interest.
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