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We determine the binding mode of a macrocyclic radicicol-like oxime to yeast HSP90 by combining computer simulations and experimental measurements.
By combining computer simulations with laboratory experiments, an international research team revealed something new about a molecular pathway that enables roughly half of all medications to achieve their desired effects – but is also responsible for many side effects.
Writing in the journal Nature, Gutjahr and colleagues from the UK and US reveal how they unpicked the conundrum by combining computer simulations with an analysis of fossil shells from microscopic single-cell organisms found within a sediment core from the north-east Atlantic Ocean.
This study, by combining computer simulations and the cooperative shear model (Johnson and Samwer, 2005 [12]), found that, at the athermal limit, the yield strain of metallic glass can be as high as ∼10% in pure shear, and the corresponding ideal shear strength is G/10 (where G is the shear modulus), at which shear bands nucleate homogeneously in the metallic glass.
By combining computer simulations according to a succession of statistical experimental designs, computer graphics, automatic image analysis, human sensory descriptive analysis and multivariate data modelling, we derive a pattern descriptor model of those macroscopic, emergent aspects of the patterns that we consider of interest.
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All the studies combine computer simulations and experiments.
She combined computer simulations of garbage and the birds, as well as their eating habits, to see where the worst problems are.
This interesting paper combines computer simulations and electron tomography to understand spindle mechanics.
This study combined computer simulation and field data from Kenya to address its aims.
In the present study, we identify situations in which the effects of collaboration emerge, and why they emerge, by combining a computer simulation method that employs our computational model as a cognitive simulator with a method based on laboratory studies.
Liu and Eck (2008) describe artificial crime analyses and simulation as methods to reveal hidden processes of urban crimes by combining criminology, computer simulation, and geographic information systems [1].
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