The TFs and their target genes were identified and organized into a module by combining comparative promoter analysis, gene expression data and known gene interactions.
To obtain highly advanced working draft sequences for the BACs, we developed a strategy to assemble large parts of the BAC sequences by combining comparative genomics, detailed repeat analysis and use of low-quality reads from 454 sequencing.
By combining transcriptional profiling, comparative genomics and culture-based arrays, these E. lenta strains were identified as carrying a two-gene cardiac glycoside reductase (cgr) operon that is transcriptionally activated by digoxin.
By combining comparative analysis and coexpression networks, this study provides novel biomarkers and research targets for ameloblast differentiation and the potential for their application in enamel regeneration.
Here such regions were identified by combining comparative sequence analysis, linkage analyses and detection of regions with extreme values of population recombination rate.
By combining comparative and phylogenetic approaches using more than 500 prokaryotic genomes, we characterized the global T6SS genetic structure in terms of conservation, evolution and genomic organization.
He and colleagues are developing a framework to facilitate applications in the fields of health, environment, and bioenergy by combining comparative functional genomics and genetics, quantitative measurement of cellular dynamics, systems biological modeling of cellular networks, and cellular design.
By combining comparative genomics with microarray and bioinformatic analyses, we have identified four additional genes likely to be involved in CHL production, and we confirmed the participation of three of these in antibiotic biosynthesis by mutational analyses.
Moreover, to explore the native proteins putatively secreted by this fungus, we also analysed its predicted secretome by combining comparative in silico predictions for classically secreted proteins with experimental data derived from two-dimensional (2-D) gel electrophoresis.
