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We investigated the nature of epistatic interactions among non-synonymous mutations, contributing to the phenotypic variation, in the three genes, and discovered that most of the variation is captured by combinatorial permutations of allelic variants at three loci (Fig. 6C).
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Among the combinatorial permutations of NN (in CGNNCG), we did not find CGGCCG, CGAACG, CGATCG, CGAGCG, and CGACCG.
Real combinatorial chemistry, meaning the combinatorial permutation of element combinations or synthesis parameters involving statistical synthetic approaches leading to true combinatorial libraries of new functional materials supported by computer aided designs, was not presented yet in scientific community of inorganic solid state chemistry.
However, the algorithm by McKay implemented in InChI allows one to avoid a combinatorial explosion in typical chemical structures, obtain equivalence classes, and even the order of the permutation group and its generators).
One could speculate that the correlation 0.749 can be achieved by combinatorial regression of any profiles, and thus we tested this possibility by performing the same regression analysis 100,000 times with random permutations of explanatory variables, that is, either U0126 or wortmannin profiles (see Supplementary Method 5.2 online).
Controlled by combinatorial action of signalling gradients.
Motor pattern selection by combinatorial code of interneuronal pathways.
Understanding ubiquitin substrate specificity is a complex combinatorial question, as it is conferred by unique permutations of E1, E2 and E3 enzymes.
Significance was tested by 1000 permutations of strain phenotypes.
P values were calculated by 1000 permutations of sample labels and by pooling permutation F values across probes.
Our humanization approach of CDR grafting plus permutations of FR residues by combinatorial library screening can be applied to other animal antibodies containing unique binding motifs on CDRs specific to posttranslationally modified epitopes.
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