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Molecular hybridization is an emerging approach to design novel ligands by combination of two or more pharmacophoric subunits of known bioactive compounds.
The objective of this study was to prepare and evaluate in situ forming gel systems designed by combination of two poloxamers (P407 and P188) and hydroxypropylmethylcellulose (HPMC) for prolonged release of heparin.
Also, as these pockets have different size and shape, inhibitory activity as well as selectivity of the 4-aminoethylpiperazinyl aryl ketones against 5-HT7R and 5-HT1AR seemed to be determined by combination of two hydrophobic substituents attached at both ends of the title compounds.
A novel bifunctional initiator 2,2,2-trichloroethanol (TCE) is used for the chemoenzymatic synthesis of AB-type diblock copolymer polycaprolactone-block-polystyrene (PCL-b-PSt) by combination of two fundamentally different synthetic techniques: enzymatic ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and atom transfer radical polymerization (ATRP) of styrene (St).
False negative for one marker was compensated for by a positive finding for one or both of the other markers, such that the sensitivity achieved by combination of two markers was higher than that achieved by either marker alone.
A flux pattern is called an elementary flux pattern if it cannot be generated by combination of two or more different flux patterns.
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The effects of these substances were synergistic, and the maximum effect was observed by combination of three agents.
By combination of three isotypes, the specificity of the tests decreased slightly to 91.5%9595% CI, 87.0% to 94.8%).
By combination of three isotypes, for all active tuberculosis patients, the test sensitivity increased to 70.4% with the specificity being 91.5%.
Table 5 reports the negative predictive values (NPV) obtained by combination of three different diagnostic cutoffs for MMP8 and D-dimer.
The ability of a single biochemical marker to detect PHT was improved by combination of three markers describing different aspects of fibrogenesis: collagen degradation, collagen formation, and noncollagen degradation.
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