Sentence examples for by clonal selection of from inspiring English sources

The udg ORF was subsequently positioned under the control of the CMV IE-chicken ß-Actin promoter/enhancer element in the pCAN expression vector to yield pCANudg. DF-1-derived cell lines that constitutively express UDGMVA were generated by calcium phosphate-mediated transfection of the udg-expression plasmid pCANudg into DF-1 cells followed by clonal selection of G418R cells.

Further improvement in the fusion efficiency can be expected by clonal selection of donor cells with a high level of MV-F/H expression.

This finding may well be explained by clonal selection of less differentiated receptor negative cells during the metastatic process, for example, elicited by adjuvant hormonal treatment [ 12, 35, 36].

One mechanism of conversion from positive to negative may well be explained by clonal selection of HER2 negative cells during the metastatic process, for example, elicited by trastuzumab therapy [ 39].

Incomplete deletion of floxed Brg1 alleles by Le-cre followed by clonal selection of viable cells and/or prolonged stability of Brg1 proteins in lens cells precludes any definitive conclusions about the potential role of Brg1 in lens lineage formation and lens placode invagination.

Furthermore, we provide data supporting the concept that the presence and persistence of lymphocytes within ovarian carcinomas may be triggered by clonal selection and/or restriction of T lymphocytes against specific (tumour cell) antigens.

In fact, at least part of the discrepant cases might arise by a clonal selection of HER2-positive cells over disease progression.

On the other hand, the number of cells obtained by clonal selection was extremely low and most of the clones were unable to reach a high number of passages in cultures.

Transition of the prostatic epithelium from androgen dependence to androgen independence may occur by clonal selection from a heterogeneous population of androgen-dependent cells during androgen deprivation.

The Goldie-Coldman model [ 35] was the first major attempt to place the theory of the evolution of drug resistance by clonal selection into a sound mathematical basis.

Because multiple rounds of mutation are followed by clonal selection during tumor evolution, selection against cells with lethal combinations of mutations will produce mutual exclusivity.