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Transition of the prostatic epithelium from androgen dependence to androgen independence may occur by clonal selection from a heterogeneous population of androgen-dependent cells during androgen deprivation.
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Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology.
ML-20 cells were derived from The Lombardi Cancer Center MCF-7 cells by clonal selection after transfection with a CMV-driven expression plasmid encoding bacterial β-galactosidase.
One mechanism of conversion from positive to negative may well be explained by clonal selection of HER2 negative cells during the metastatic process, for example, elicited by trastuzumab therapy [ 39].
Reflecting the genesis of tumors as an evolutionary process driven by clonal selection.
An algorithm for resource allocation in cloud computing environments inspired by clonal selection algorithm is proposed.
Despite these encouraging data, the low number of cells that can be isolated by clonal selection make this approach hardly applicable to cell-based therapy, until the identification of growth factors able to enhance the cell yield from isolated clones.
A limitation of the present work is represented by the low number of cells obtained by clonal selection, resulting in restrictions to the possible analysis.
A stable cell line overexpressing Grx1 was generated by electroporating SH-SY5Y with 20 µg of linearized construct overexpressing Grx1, followed by clonal selection.
The main conclusion from the genomic study is that breast tumours undergoing neoadjuvant endocrine therapy show clonal variation that could be explained by clonal selection.
Alternatively, they may be generated by clonal selection.
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