Sentence examples for by chronic activation of from inspiring English sources
Previous work showed modest induction of MBF-dependent transcripts 60 minutes after irradiation with 500 grays, suggesting that MBF may be regulated by chronic activation of the G2 DNA checkpoint [19].
It is accompanied by chronic activation of diacylglycerol-sensitive protein kinase C [ 69].
HF is characterized by chronic activation of neuro-hormonal pathways representing a compensatory response to overcome depressed cardiac function.
HF is characterized by chronic activation of natriuretic peptides system: the secretion and circulation of cardiac natriuretic peptides (NPs) are markedly increased during HF.
We chose the antibody-secreting capacity of plasma cells, normally characterized by chronic activation of the UPR and high levels of XBP1s expression, as a physiological example to confirm the role of RTCB in XBP1 mRNA splicing in vivo.
More importantly, sestrins appear to function as a negative feedback regulator of mTOR that integrates metabolic and stress inputs and prevents gero-pathologies caused by chronic activation of mTOR.
The biphasic nature of microglia activation (acute activation in OB followed by chronic activation at the site of ischemic lesion) was suggested to be a result of the distinct neuroanatomical location maintained by the OB.
It is beyond the scope of this study to reveal whether the decreased amounts of NREM sleep can be attributed to attenuated levels of SWA, but this would implicate that reduced SWA is an intrinsic sleep-physiological feature of the HR mouse line, which might be brought about by a chronic activation of the CRH system [6], [75].
However, a derangement in redox homeostasis, resulting in sustained levels of oxidative stress and related mediators, can play a significant role in the pathogenesis of major human diseases characterized by chronic inflammation, chronic activation of wound healing and tissue fibrogenesis.
A significant derangement in redox homeostasis, resulting in sustained levels of oxidative stress and related mediators, plays a role in the pathogenesis of human diseases characterized by chronic inflammation, chronic activation of wound healing and tissue fibrogenesis, including chronic liver diseases.
Infection by the human immunodeficiency virus (HIV) is characterized by functional impairment and chronic activation of T lymphocytes, the causes of which are largely unexplained.
