Sentence examples for by chromatin structure and from inspiring English sources

Although DNA sequence is the primary recognition element in genome regulatory sites, access of the receptor to these sites is strongly modulated by chromatin structure, and the subsequent reorganization of local nucleoprotein domains is a key component of receptor function.

The nucleus is maintained in a prestressed state within eukaryotic cells, stabilized mechanically by chromatin structure and other nuclear components on its inside, and cytoskeletal components on its outside.

Our findings provide a framework for understanding how quiescence is globally regulated by chromatin structure and other factors in budding yeast.

Recent studies provided evidence that alternative splice site choice is influenced by chromatin structure and histone modifications mainly through two mechanisms, kinetic coupling [ 13– 18] or chromatin-splicing adaptor systems [ 13, 19– 22].

Although γ-H2AX foci have been used to analyze endogenous and induced DSBs in most studies, recent data have indicated that γ-H2AX foci may also be produced by chromatin structure alternations and may not contain DSBs (Banath et al. 2004; Han et al. 2006; Suzuki et al. 2006; Yu et al. 2006).

CARM1 downregulation has thus a dual role: it acts directly on pluripotency genes by regulating chromatin structure and indirectly by priming developmental genes through SirT1 downregulation.

They can bind methylated sequences, preventing them from interacting with other TFs, by altering chromatin structure and possibly by sequestering other TFs [ 68].

As DNA methylation regulates transcript levels by altering chromatin structure and regulating the elongation by RNA polymerase II (RNApII) and through the human transcription elongation regulator interacting with RNApII at the Serine 2 position (RNApIISer2), we determined whether treatment with 5-azaC and VitC modulates DNA methylation at exon 2 of POLGA and thus RNApII function.

Histone acetylation promotes gene transcription by relaxing chromatin structure and facilitating access to DNA by the transcriptional machinery, whereas histone deacetylation promotes transcriptional repression by condensing chromatin structure.

Epigenetic mechanisms involving DNA methylation, histone modification, histone variants and nucleosome positioning, and noncoding RNAs regulate cell-, tissue-, and developmental stage-specific gene expression by influencing chromatin structure and modulating interactions between proteins and DNA.

Thus the qPCR assay highlights two separate mechanisms for TSA to enhance the luciferase signal of the DMD minigene construct – one as a general effecter of gene transcription by modulating chromatin structure, and another as a modulator of pre-mRNA splicing.