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Thus, the function of a protein can sometimes be deduced by characterizing its binding partners.
By characterizing its binding in these cell lines, we could compare TR4 binding sites with other transcription factor binding sites and histone marks determined by other ENCODE groups examining these same cell types.
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Independent groups have confirmed this ligand-receptor system by characterizing the binding of CGRRAGGSC.
Recent preclinical studies have demonstrated the use of properly folded trimeric HIV-1 envelope proteins as immunogen for eliciting protecting immune response in macaques.Trimeric gp145 protein of Indian clade C HIV-1 (93IN101) was characterized for antigenicity by evaluating its binding to sCD4, and several monoclonal antibodies to HIV-1 by bio-layer interferometry.
Acetaminophen represented an ideal test case as it was shown to bind BET bromodomains via X-ray crystallography, but its affinity for its target was reported as too weak for characterizing Brd4(1) binding by fluorescence anisotropy or TR-FRET.
We used electron microscopy to characterize microtubule binding by doublecortin and visualize its binding site.
The family of RIN proteins is characterized by its Vps9 domain and its binding affinity for Rab5a.
We show that DS is the most active origin of replication present in the mini-EBV genome regardless of its location, and it is characterized by the binding of the origin recognition complex (ORC) allowing subsequent replication initiation.
The M12 peptide sequence was further characterized by reverse binding using its specific IgG antibodies to capture and identify its antigen target by MS, which led us to the CAIII protein.
The canonical Wnt pathway is characterized by binding of Wnt proteins, through transmembrane receptors, to ultimately form a complex with axin to induce its dephosphorylation.
That unusual bacteria-GO self-organization could be characterized by binding, available on the GO surface.
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