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Authors concluded that the delamination length can be reduced by changing the binding sequence to one with shorter binder spacing/ smaller unit cell size.
Variations of the aptamer selection strategies can be used to isolate catalytic nucleic acid sequences by changing the binding selection step of the aptamer selection process to an activity selection step (Fig. 15).
Therefore, we proposed that by changing the binding affinity of the fibroblast to collagen, integrins are causing the induction of intracellular ROS, which leads to oxidant stress and caspase-3 activation.
Recently, some novel antibody conjugating strategies are being developed in our group to enhance tumor accumulation by changing the binding site on the mAbs [ 44].
As is known, the polymorphisms in the COX-2 promoter may have an important effect on gene transcriptional activity by changing the binding capacity of certain nuclear proteins, thereby affecting COX-2 expression.
These reports are suggestive and supportive of our hypothesis that the rare allele of rs561681 could reduce DLC1 expression by changing the binding sites of transcription factors such as AP1 and CREB, and the heterodimer produced by the heterozygote (aA) amplifies the effect of CDK6.
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This may occur by drastically changing the binding mode, for instance, by causing the peptide to rotate.
The release kinetics of growth factors can be molecularly modulated by either changing the binding affinity of the aptamer or by using a triggering effector.
Indeed, our hypothesis can be validated experimentally; by changing the Gcn4p binding site for gene ILV5 to have a lower binding affinity, it predicts that the regulation of the amino acid biosynthesis pathway will be disrupted more easily.
To date, it has been observed that the FCRL3 −169T>C SNP affects the expression of FCRL3 by changing the affinity binding of nuclear factor-kappa B (NF-κB) to its promoter.
Recently, we proposed that the ATP-binding event in NBD94 triggers a conformation rearrangement within the protein, going along with alterations in Py235 and thereby changing the binding strength of this reticulocyte binding-like protein to the red blood cell, as reflected by erythrocyte binding assays performed with Py235 of P. yoelii [27].
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